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2011 28618:16131 9. MicroRNA 155 contributes case study the development of alcoholic liver harm. MicroRNAs miRs are small noncoding RNA molecules that adjust the expression of aim genes concerned in a big range of organic processes. Among them, miR 125b, miR 146a and miR 155 have been diagnosed as critical mediators of innate immune responses and inflammation. Considering the knowledge role that miRs may play within the inflammatory methods concerned in alcoholic liver disease ALD, the current study evaluated the hypothesis that miR 155, miR 146a and/or miR 125b could play a task within the advancement of alcoholic liver harm. Researchers demonstrated that continual alcohol publicity augments TNF production via miR 155 in liver macrophages. In addition, they found that miR 155 stabilizes TNF mRNA after alcohol publicity, thus expanding the unencumber of this inflammatory mediator. These data aid the idea that miRs contribute case study the development of alcoholic liver harm and imply that miR 155 could be a possible therapeutic objective in ALD. Bala S, et al. J Biol Chem. 2011 Jan 14;2862:1436 44.
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